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GlossaryVaginal Dryness (Vaginal Atrophy)

reduced lubrication in vaginal tissues causing discomfort and pain

Vaginal dryness refers to a condition where the vaginal tissues are not adequately lubricated, often leading to discomfort, itching, and pain during intercourse. This can be caused by hormonal changes, particularly a decrease in estrogen levels during menopause, but can also result from certain medications, stress, or underlying health conditions. It is sometimes referred to as vaginal atrophy or atrophic vaginitis when it involves thinning and inflammation of the vaginal walls.

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research Histological and Gene Expression Analysis of the Effects of Menopause Status and Hormone Therapy on the Vaginal Introitus and Labia Majora

7 citations , January 2019 in “Journal of clinical medicine research”

Menopause causes significant changes in the vaginal introitus, but less so in the labia majora, which may lead to symptoms of vaginal atrophy.

research A Phase II Study of Vaginal Testosterone Cream Versus Estring for Vaginal Dryness or Decreased Libido in Women with Early Stage Breast Cancer Treated with Aromatase Inhibitors

9 citations , December 2009 in “Cancer Research”

Both vaginal testosterone cream and Estring effectively manage vaginal dryness in women with early-stage breast cancer on aromatase inhibitors.

research Anatomical and Dermatologic Manifestations of Estrogen Deficiency in Postmenopausal Women: A Systematic Review

December 2025 in “Pakistan Journal of Health Sciences”

Estrogen deficiency in postmenopausal women can cause skin and hair issues, but local estrogen therapies help improve vaginal health.

research Platelet-Rich Plasma and Genital Rejuvenation

3 citations , January 2019 in “PubMed”

Platelet-rich plasma may be effective for genital rejuvenation and deserves more research.

research Treatment of Vulvovaginal Erosive and Stenosing Lichen Planus by Surgical Dilatation and Methotrexate

October 2007 in “Obstetrical & Gynecological Survey”

Low-dose methotrexate, combined with surgical and local treatments, effectively treats severe vulvovaginal lichen planus.

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community Attempting to assist people with gyno sides on finasteride

in Research/Science 24 upvotes 1 year ago

Finasteride can cause gynecomastia due to hormonal imbalances. Management includes consulting an endocrinologist and using aromatase inhibitors like anastrozole or supplements like DIM and zinc.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 3 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

community Estrogen is an anabolic for scalp hair, if you mix it with growth stimulants such as oral minoxidil. All we need is an artificial SARM-estrogen that will work only with hair and will be invisible for the rest of the body + some next level AA only for hair – goodbye hair transplant industry

in Transgender 137 upvotes 4 years ago

Hair loss discussion mentions using estrogen mixed with growth stimulants like oral minoxidil for scalp hair growth. Idea proposed for an artificial SARM-estrogen that only affects hair without body side effects.

community So depressed and upset with how much progress I’ve lost

in Chat 51 upvotes 2 years ago

A 20-year-old started taking finasteride for hair loss at 18, saw improvement, but developed erectile dysfunction (ED) after taking accutane. Despite stopping both medications, ED persisted, and hair loss worsened. Advice given includes considering tadalafil for ED, resuming finasteride, using minoxidil, and addressing psychological factors through positive thinking and lifestyle changes.

community So I was wondering what stack are we on boys? 🤔

in Satire 479 upvotes 2 years ago

Treatments for hair loss, including microneedling, finasteride, minoxidil, dutasteride, RU-58841, pyrilutamide, pumpkin seed oil, rosemary water, orchiectomy, and estrogen.

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