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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
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5 / 17 resultslearn Microneedling
technique to create small wounds in skin to activate collagen production and hair growth
learn Overview
learn KY19382
compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles
learn Dutasteride
Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity
Research
5 / 1000+ results research TGFβ ‐mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound‐induced skin fibrosis
This study establishes a wound-induced skin fibrosis (WISF) mouse model that mimics human fibrotic skin diseases, characterized by excessive collagen deposition and loss of dermal adipocytes. The research identifies TGFβ as a key signal that inhibits the differentiation of hypodermal interstitial adipocyte progenitors (HI-APs) into adipocytes, instead promoting their fibrogenic potential. The study shows that blocking TGFβ signaling can reduce the abundance of extracellular matrix-producing adipocyte progenitors, suggesting that targeting HI-APs and adipogenesis could lead to new treatments for fibrotic skin conditions. Analysis of human scleroderma tissues supports these findings, showing a negative correlation between adipogenic and fibrogenic gene expression.
research The Androgen-THY1 Axis Mediates Sexual Dimorphism in Dermal Adipogenesis and Fibrosis
Androgens reduce THY1 in skin cells, leading to less fat, more fibrosis, and worse healing in males.
research Understanding the Functional Contribution of Dermal Stem Cells to Hair Follicle Regeneration and Skin Wound Healing
Dermal stem cells help regenerate hair follicles and heal skin wounds.
research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair
Fat cells in the skin help start healing and form important repair cells after injury.
research Emerging Nonmetabolic Functions of Skin Fat
Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
Community Join
5 / 1000+ resultscommunity Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.
Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.
community Verteporfin with Microneedling (3mm-3.5mm): Bald to Full Head of Hair? Theory
The conversation is about using Verteporfin with microneedling as a potential hair loss treatment that may regenerate hair follicles with minimal scarring. There are concerns about the optimal dosage and the DHT sensitivity of the new follicles.
community Occipitalis Muscle Tension Theory
Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.
community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year
A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.
community Got my Oleic fatty acid they used in Korean study. Fuck you mice!
Oleic acid and microneedling are being explored for hair regrowth, but results are mixed. Addressing DHT and fibrosis is crucial, with treatments like finasteride, minoxidil, and scalp massage also discussed.