Evidence of Increased 3-Alpha-Androstanediol Glucuronide in Female Pattern Alopecia: A Cross-Sectional Observational Study Evaluating Ovarian, Adrenal, and Peripheral Androgens

    Arunesh Padmini Kathirvelu, Kabir Sardana, Lokesh Kumar Sharma, Ananta Khurana, Savitha Sharath
    TLDR Higher levels of 3α-diol G are linked to more severe female pattern hair loss.
    This study investigated the role of androgens in female pattern hair loss (FPHL) by evaluating ovarian, adrenal, and peripheral androgens, specifically 3α-androstanediol glucuronide (3α-diol G), in 44 Indian women with FPHL compared to 30 healthy controls. The results showed that serum 3α-diol G levels were significantly higher in women with FPHL and positively correlated with the clinical severity of the condition. Other androgen levels did not differ significantly between the groups. The study concluded that 3α-diol G is a promising biomarker for peripheral hyperandrogenism in FPHL, correlating with disease severity and potentially aiding in monitoring antiandrogen therapy.
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