3D Bioprinting Of Hepatocyte-Derived Exosome-Reinforced Skin Organoid For Efficient Skin Regeneration

    June 2026 in “ Nano Research ”
    Bhavana Rajbanshi, Churong Xu, Surendra Shrestha, Ruihan Hao, Yuxin Qi, Zhouyi Duan, Ding Ma, Qichen Li, Fangzheng Cheng, Liming Dai, Miao Jiang, Xiaoling Zhang, Bingjun Zhang, Jingjun Zhao
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    TLDR 3D bioprinted skin using liver cell exosomes helps heal wounds better.
    This study explores the use of hepatic exosomes, rich in organic selenium protein, for skin regeneration. Researchers developed a 3D bio-printed skin organoid scaffold using these exosomes encapsulated in GECM bio-ink to mimic natural skin structure. The skin construct enhances wound healing by promoting tissue regeneration and reducing inflammation. This innovative approach offers promising insights for treating chronic and difficult-to-heal skin conditions.
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