Three-Dimensional Organoid System Transplantation Technologies in Future Treatment of Central Nervous System Diseases

The document reviewed the potential of three-dimensional organoid system transplantation as a future treatment for central nervous system (CNS) diseases, highlighting its advantages over traditional stem cell therapy, such as higher survival rates and better integration with host tissue. It categorized research into three approaches: direct organization of region-specific organoids, assembly of organ-specific progenitor cells, and induction of multilayer organoids. The study emphasized the importance of spatiotemporal control strategies and manipulation of signals to direct differentiation and self-organization of organoids. Despite advancements in understanding brain development, most research focused on cellular and molecular mechanisms rather than direct disease treatment, underscoring the need for further exploration of organoid transplantation's clinical applications in CNS diseases.