Impacts of Anabolic-Androgenic Steroid Supplementation on Female Health and Offspring: Mechanisms, Side Effects, and Medical Perspectives

    November 2024 in “ Saudi Pharmaceutical Journal ”
    Beatriz Menegate Santos, Jaqueline Pérola Souza, Laureci da Silva Goulart, Jéssica Petrine Castro Pereira, Fernando H.F. Alves, Bruno Del Bianco Borges
    TLDR Anabolic-androgenic steroids can harm women's health and their offspring.
    The document discusses the rising use of Anabolic-androgenic steroids (AAS) among women for aesthetic purposes and the associated health risks due to limited understanding of their effects on females. Prolonged or high-dose AAS use can cause mood changes, psychiatric disorders, voice deepening, clitoromegaly, menstrual irregularities, and cardiovascular issues, leading medical societies to advise against their use. Research in female rodents indicates AAS can increase aggression, inflammation, and negatively affect the heart and blood vessels. Maternal AAS use during pregnancy may harm offspring's reproductive, neuronal, and metabolic health. The review seeks to clarify AAS's impact on female health and offspring, identify common anabolic substances, and present medical perspectives on AAS use.
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