Acellular dermal matrix hydrogels promote healing of radiation-induced skin injury in a rat model

    January 2024 in “ Journal of Materials Chemistry B ”
    Xin Liu, Guo Tian, Zhifeng Huang, Sen Chen, Li Chen, Chenyang Li, Tian Tian, Yerong Qian, Lifei Yang, Junxi Xiang, Qiufang Liu, Peng Liu
    TLDR ADM hydrogels help heal radiation skin injuries.
    The study investigates the use of acellular dermal matrix (ADM) hydrogels for treating radiation-induced skin injury (RISI) in a rat model. ADM hydrogels, derived from porcine dermis, were evaluated for their therapeutic effects on RISI. The results showed that ADM hydrogel treatment significantly reduced wound area and radiation injury scores, decreased apoptosis, and increased epithelial thickness and hair follicle regeneration compared to the control group. The hydrogel also promoted angiogenesis, vascular maturation, and M2 macrophage polarization, while reducing pro-inflammatory cytokines (IL-1β and IL-6) and increasing the anti-inflammatory cytokine IL-10. These findings suggest that ADM hydrogels could be a promising biomaterial for managing RISI by modulating the inflammatory microenvironment and enhancing angiogenesis.
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