Synergistic Wound Healing: Unraveling the Multi-Target Effects of Traditional Chinese Medicine and Its Biomaterials on Chronic Wound Pathways

This review explores the multi-target effects of Traditional Chinese Medicine (TCM) and its biomaterials on chronic wound healing, focusing on diabetic ulcers, radiation-induced ulcers, and burns. TCM components like Scutellaria baicalensis, curcumin, and Panax notoginseng regulate key pathways involved in oxidative stress, inflammation, angiogenesis, and extracellular matrix remodeling. Innovative biomaterials, such as nanofibrous scaffolds and hydrogels, improve the delivery and efficacy of these natural compounds. Despite advancements, challenges remain in optimizing these systems and understanding self-assembly mechanisms. Future research should aim to enhance material stability and integrate insights from herbal medicine, nanotechnology, and regenerative biology to improve chronic wound management.