Adaptive Regulatory Mechanisms of Alopecia Areata

The study examined 48 patients with alopecia areata (AA) to assess the condition of adaptive hormones like cortisol and insulin, and the dermatologic life quality index (DLQI). It found a positive correlation between DLQI and factors such as early age, severe stage, and hair loss over 12 months. Two types of hormonal reactions were identified: an increase or decrease in cortisol and insulin levels depending on the activity, severity, and duration of AA. An increase in the coefficient "K" indicated heightened tension of adaptive potential in patients with disease progression, while a decrease in "K" during chronic stages suggested depletion of adaptive mechanisms. These maladaptive processes could be potential therapeutic targets.