Serum Adiponectin Level Is Negatively Related to Insulin Resistance in Women with Polycystic Ovary Syndrome

The study involving 154 women with polycystic ovary syndrome (PCOS) found that serum adiponectin (APN) levels are negatively correlated with insulin resistance (IR), indicating that lower APN levels are associated with higher IR. Women with PCOS and IR had significantly lower APN levels compared to those without IR. An APN level below 5.225 mg/L was identified as an effective predictor of IR, suggesting that APN could serve as a clinical marker for early diagnosis of IR in PCOS. Despite some limitations, the study supports the role of APN as a protective factor against IR and highlights its potential in preventing metabolic-related health issues in women with PCOS.