Acellular Dermal Matrix Hydrogels Promote Healing of Radiation-Induced Skin Injury in a Rat Model
January 2024
in “
Journal of Materials Chemistry B
”
acellular dermal matrix ADM hydrogels radiation-induced skin injury RISI porcine dermis apoptosis epithelial thickness hair follicle regeneration angiogenesis vascular maturation M2 macrophage polarization pro-inflammatory cytokines IL-1β IL-6 anti-inflammatory cytokine IL-10 ADM hydrogels skin injury wound healing inflammation cytokines
TLDR ADM hydrogels help heal radiation skin injuries.
The study investigates the use of acellular dermal matrix (ADM) hydrogels for treating radiation-induced skin injury (RISI) in a rat model. ADM hydrogels, derived from porcine dermis, were evaluated for their therapeutic effects on RISI. The results showed that ADM hydrogel treatment significantly reduced wound area and radiation injury scores, decreased apoptosis, and increased epithelial thickness and hair follicle regeneration compared to the control group. The hydrogel also promoted angiogenesis, vascular maturation, and M2 macrophage polarization, while reducing pro-inflammatory cytokines (IL-1β and IL-6) and increasing the anti-inflammatory cytokine IL-10. These findings suggest that ADM hydrogels could be a promising biomaterial for managing RISI by modulating the inflammatory microenvironment and enhancing angiogenesis.
