Advances in Hyaluronic Acid-Based Biomaterials: Applications in Cancer Therapy, Wound Healing, and Disease Management

Hyaluronic acid (HA) is a versatile biomaterial with significant applications in cancer therapy, wound healing, and disease management due to its compatibility with biological tissues and ability to form hydrogels. HA-functionalized nanoparticles enhance targeted drug delivery in cancer treatment by exploiting CD44 receptors on cancer cells. In wound healing, HA-based hydrogels regulate inflammation, promote angiogenesis, and aid extracellular matrix remodeling. HA's anti-inflammatory and antioxidant properties are beneficial in treating chronic inflammatory conditions like osteoarthritis and inflammatory bowel disease. Recent advancements highlight HA's potential in antibacterial applications, diabetes control, and treating cardiovascular and neurological conditions, with ongoing development of intelligent drug delivery systems and bioactive scaffolds for tissue repair and disease management.