The Hair Loss Encyclopedia

Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

February 2013 in “ Journal of The American Academy of Dermatology ”

Aline Amoretti, Humberto Laydner, Wilma F. Bergfeld

androgenetic alopecia vertex pattern androgenetic alopecia AGA male pattern baldness

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TLDR Vertex pattern hair loss linked to higher prostate cancer risk.

This systematic review and meta-analysis found that vertex pattern androgenetic alopecia (AGA) was associated with an increased risk of prostate cancer, while other patterns of AGA did not show a significant association with prostate cancer. The study suggests that further studies are needed to better understand the potential association between vertex pattern AGA and prostate cancer.

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Research cited in this study

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Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

research Differential Expression Analysis of Balding and Nonbalding Dermal Papilla MicroRNAs in Male Pattern Baldness Using a MicroRNA Amplification Profiling Method

29 citations , October 2011 in “British Journal of Dermatology”

Certain microRNAs are more common in balding areas and might be involved in male pattern baldness.

Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

research Androgenetic Alopecia as an Early Marker of Benign Prostatic Hyperplasia

28 citations , August 2011 in “Journal of The American Academy of Dermatology”

Early hair loss may indicate prostate issues.

Male Pattern Baldness and the Risk of Prostate Cancer

research Male Pattern Baldness and the Risk of Prostate Cancer

38 citations , February 2011 in “Annals of Oncology”

Men who experienced baldness at age 20 may have double the risk of getting prostate cancer.

Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations , November 2010 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

Androgenic Alopecia Is Not Useful as an Indicator of Men at High Risk of Prostate Cancer

research Androgenic Alopecia Is Not Useful as an Indicator of Men at High Risk of Prostate Cancer

28 citations , June 2010 in “European Journal of Cancer”

Baldness at age 40 is not linked to a higher risk of aggressive prostate cancer.

research Male Pattern Baldness and Prostate Cancer Risk in a Population-Based Case-Control Study

29 citations , March 2010 in “Cancer epidemiology”

Men who start losing hair at age 30 may have a lower risk of prostate cancer.

research MicroRNAs Take Part in Pathophysiology and Pathogenesis of Male Pattern Baldness

21 citations , October 2009 in “Molecular Biology Reports”

Baldness, Benign Prostate Hyperplasia, Prostate Cancer, and Androgen Levels

research Baldness, Benign Prostate Hyperplasia, Prostate Cancer, and Androgen Levels

30 citations , January 2008 in “The Aging Male”

The study found no link between baldness patterns and androgen levels in men with benign prostate enlargement or prostate cancer.

research Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

299 citations , March 2001 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to specific genetic variations in the androgen receptor gene.

research Risk Factors for Prostate Cancer: A Case-Control Study in Greece

127 citations , March 1999 in “International Journal of Cancer”

Urban living may increase prostate cancer risk, while early sexual activity might reduce it.