Ageratum houstonianum Extract and Agerarin Promote Hair Growth via MAPK/AP-1 Axis-Dependent Upregulation of SCUBE3 in Human Dermal Papilla Cells

The study explores the effects of Ageratum houstonianum extract (AHE) and its active compound agerarin on hair growth by focusing on their ability to upregulate SCUBE3 expression in human dermal papilla cells via the MAPK/AP-1 signaling pathway. Using an ex vivo human hair follicle model, the researchers found that treatment with AHE and agerarin significantly increased hair follicle activation and hair elongation, suggesting their potential as therapeutic agents for hair growth. The study highlights the need for further in vivo research to confirm these findings and explore additional signaling pathways involved.