Amine-Functionalized Chitosan/DECM Composite Promotes Cutaneous Regeneration and Hair Follicle Activation by Regulating Oxidative Stress and Inflammation

The study explores the potential of an amine-functionalized chitosan and decellularized extracellular matrix (aaCMC + h-dECM) composite for hair regeneration and skin repair. The composite effectively targets oxidative stress and inflammation, crucial for hair follicle health, by scavenging reactive oxygen species and promoting cell proliferation in vitro. In vivo, it demonstrated significant hair regrowth and wound healing in UVB-damaged mouse models, outperforming minoxidil and PBS controls. The composite activated Wnt/β-catenin signaling, reduced inflammation, and enhanced extracellular matrix deposition, restoring damaged tissue to near-normal states. These results suggest that the aaCMC + h-dECM composite is a promising alternative to current hair loss treatments, offering improved safety and regenerative outcomes.