Supercritical CO2-Decellularized Amniotic ECM Hydrogel Promotes Immunomodulatory Skin Regeneration
June 2026
in “
Materials Today Bio
”
decellularized porcine amniotic membrane dPAM hydrogel supercritical carbon dioxide angiogenesis pro-inflammatory responses regenerative signaling human follicle-derived dermal papilla cells hair follicle biology UVB-induced skin inflammation cutaneous repair amniotic ECM hydrogel skin regeneration tissue repair
TLDR The hydrogel helps heal skin and reduce inflammation.
The study introduces a decellularized porcine amniotic membrane (dPAM) hydrogel, engineered using supercritical carbon dioxide, which effectively removes immunogenic components while preserving bioactive molecules crucial for skin regeneration. The hydrogel promotes angiogenesis, reduces pro-inflammatory responses, and enhances regenerative signaling in human follicle-derived dermal papilla cells, indicating its potential to influence hair follicle biology. In a UVB-induced skin inflammation murine model, the hydrogel demonstrated dual functionality by reducing early immune responses and promoting tissue repair. These findings suggest that dPAM hydrogel could serve as a bioactive platform for cutaneous repair and broader regenerative applications.
