TLDR AR gene variations don't affect aging markers in men.
This study investigated the relationship between androgen receptor (AR) gene polymorphisms and biological age in 131 healthy men, focusing on AR sensitivity estimated by CAG repeat length in the AR gene. Despite controlling for various factors, including testosterone levels, no relationship was found between AR CAG repeat length and biological age markers. The findings suggest that lifetime testosterone fluctuations, influenced by environmental and health factors, may obscure any potential link between AR gene polymorphisms and aging rates.
87 citations
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May 2018 in “Scientific Reports” Higher free testosterone levels in men are linked to a stronger immune response, not weaker.
40 citations
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January 2013 in “Frontiers in Endocrinology” Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.
41 citations
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October 2011 in “Clinical and Experimental Dermatology” G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.
44 citations
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January 2008 in “Fertility and Sterility” Longer CAG repeat lengths in the androgen receptor gene are linked to higher testosterone levels in women with PCOS.
10 citations
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October 2018 in “Sexual medicine reviews” Men using hair loss drugs like finasteride may experience sexual side effects like erectile dysfunction, but it's unclear who will be affected and when. Treating depression and sexual symptoms is suggested, as these men often have higher rates of both. More research is needed to understand why these side effects occur.
15 citations
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August 2010 in “Fertility and sterility” Metformin works better for adolescent girls with PCOS who have certain genetic variations.
24 citations
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April 2014 in “Oncotarget” Minoxidil can reduce functions related to androgen receptors.
26 citations
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December 2019 in “Neurobiology of Stress” Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.
