Anti-Hair Loss Activity of Healthy Human Scalp-Derived Staphylococcus Capitis KMH304 Ferment Filtrate in Human Hair-Follicle Dermal Papilla and Keratinocyte Cells

April 2026 in “ Microorganisms ”

Hye-Young Yoo, Tae Geun Gil, Na-Rin Kim, Hye-Won Lee, Sang‐Bae Choi, S.-P. Choi, Sung‐Ha Park, Byoung‐Jun Park

Staphylococcus capitis KMH304 ferment filtrate SCFF human hair-follicle dermal papilla cells keratinocyte cells androgenetic alopecia scalp barrier function antioxidant properties hair growth markers anti-aging effects

TLDR SCFF may help promote hair growth and scalp health.

The study explored the anti-hair loss potential of Staphylococcus capitis KMH304 ferment filtrate (SCFF) derived from the scalps of 20 healthy Korean participants. SCFF was tested on human hair-follicle dermal papilla cells and keratinocyte cells, showing enhanced cell viability, proliferation, and modulation of hair growth markers while reducing androgenetic alopecia-inducing markers. It also demonstrated anti-aging effects, improved scalp barrier function, and exhibited antioxidant properties. Despite the small participant pool, the findings suggest SCFF's potential as a novel cosmetic ingredient for promoting hair growth and scalp health by modulating biological pathways associated with hair loss.

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