Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

August 2018 in “ International Journal of Cosmetic Science ”

Alka Madaan, Ritu Verma, Anu Singh, Manu Jaggi

hair follicle Dermal Papilla cells DPCs in vitro model hair growth modulators cell proliferation apoptosis growth factors hair growth research hair growth treatments biomarkers hair follicle cells hair growth agents cell growth cell death growth proteins hair growth studies hair growth therapies biological markers

TLDR Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

The document from October 1, 2018, reviewed the use of hair follicle Dermal Papilla cells (DPCs) as an in vitro model for screening potential hair growth modulators. It discussed the effects of various agents on DPCs, including their impact on cell proliferation, apoptosis, and secretion of growth factors. The review highlighted the role of DPCs in hair growth research and their potential in developing new treatments. It also suggested a 3-step strategy for selecting lead candidates for hair growth modulation, which could reduce the use of experimental animals. The document concluded that DPCs are a promising target for hair growth assessment and emphasized their importance in the selection of biomarkers for hair growth studies.

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research Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

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Ecklonia cava, a type of seaweed, may help hair grow.

Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

research Induction of Insulin-Like Growth Factor-I by Cepharanthine from Dermal Papilla Cells: A Novel Potential Pathway for Hair Growth Stimulation

13 citations , October 2013 in “The Journal of Dermatology”

Cepharanthine may help hair growth by increasing IGF-I in scalp cells.

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.

research Promotion Effect of Constituents from the Root of Polygonum Multiflorum on Hair Growth

51 citations , July 2013 in “Bioorganic & Medicinal Chemistry Letters”

Compounds from Polygonum multiflorum root, especially a new one, can boost hair growth more effectively than common treatments.

research Valproic Acid Promotes Human Hair Growth in In Vitro Culture Model

48 citations , June 2013 in “Journal of Dermatological Science”

Valproic acid may help hair grow and could be a safe treatment for hair loss.

Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

research Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

39 citations , June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research The Promoting Effect of Ishige Sinicola on Hair Growth

26 citations , May 2013 in “Marine Drugs”

Ishige sinicola, a type of seaweed, may help hair grow by blocking a hair loss-related enzyme and boosting important cell growth.

The Regulatory Role of the Tetrapeptide AcSDKP in Skin and Hair Physiology and the Prevention of Aging Effects in These Tissues – A Potential Cosmetic Role

research The Regulatory Role of the Tetrapeptide AcSDKP in Skin and Hair Physiology and the Prevention of Aging Effects in These Tissues – A Potential Cosmetic Role

13 citations , March 2013 in “International Journal of Cosmetic Science”

AcSDKP may help prevent skin and hair aging and promote their growth.

research Ascorbigen Induces Dermal Papilla Cell Proliferation In Vitro, But Fails To Modulate Chemotherapy-Induced Alopecia In Vivo

2 citations , March 2013 in “Phytotherapy Research”

Ascorbigen increases hair cell growth in a lab setting but does not prevent hair loss from chemotherapy in mice.

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations , February 2013 in “PLOS ONE”

6-Gingerol, found in ginger, may slow down hair growth and could be used for hair removal.

research Effects of Glucocorticoid on Human Dermal Papilla Cells In Vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Dexamethasone may cause hair loss by stopping cell growth.

research Hair Growth Activity of Crataegus Pinnatifida on C57BL/6 Mouse Model

25 citations , November 2012 in “Phytotherapy Research”

Crataegus pinnatifida extract may help increase hair growth and thickness in mice.

research Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling

45 citations , September 2012 in “Life Sciences”

Aconiti Ciliare Tuber extract may help hair grow by activating a specific cell signaling pathway.

research Promotion Effect of Acankoreoside J, a Lupane-Triterpene in Acanthopanax Koreanum, on Hair Growth

17 citations , August 2012 in “Archives of Pharmacal Research”

Acankoreoside J from Acanthopanax koreanum may help promote hair growth.

1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration

research 1α,25-Dihydroxyvitamin D3 Modulates the Hair-Inductive Capacity of Dermal Papilla Cells: Therapeutic Potential for Hair Regeneration

32 citations , July 2012 in “Stem Cells Translational Medicine”

Vitamin D3 can help improve hair growth by enhancing the function of specific skin cells and could be useful in hair regeneration treatments.

Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

research Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

41 citations , July 2012 in “Stem Cells and Development”

Low-dose UVB light improves hair growth effects of certain stem cells by increasing reactive oxygen species.

research VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK

120 citations , May 2012 in “Experimental Cell Research”

VEGF promotes hair follicle cell growth through the VEGFR-2/ERK pathway.

research Effect of Dieckol, a Component of Ecklonia Cava, on the Promotion of Hair Growth

34 citations , May 2012 in “International Journal of Molecular Sciences”

Dieckol from Ecklonia cava may help hair growth and could be a potential hair loss treatment.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Analysis of the MicroRNA Expression Profile of Normal Human Dermal Papilla Cells Treated with 5α-Dihydrotestosterone

22 citations , March 2012 in “Molecular Medicine Reports”

DHT affects hair follicle cells by changing microRNA levels, leading to less cell growth and more cell death.

research Progress in Relevant Growth Factors Promoting the Growth of Hair Follicles

6 citations , February 2012 in “American Journal of Animal and Veterinary Sciences”

Growth factors are crucial for hair follicle growth and development.

research Hair-Loss Preventing Effect of Grateloupia Elliptica

19 citations , January 2012 in “Biomolecules & Therapeutics”

Grateloupia elliptica extract may help prevent hair loss and promote hair growth.

research Hair Growth Promoting Effect of Black Soybean Extract In Vitro and In Vivo

13 citations , December 2011 in “Korean Journal of Food Science and Technology”

Black soybean extract helps promote hair growth and could prevent hair loss.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

research Impact of Taxol on Dermal Papilla Cells: A Proteomics and Bioinformatics Analysis

9 citations , October 2011 in “Journal of proteomics”

Taxol damages hair growth cells, causing hair loss.

research Fructus Panax Ginseng Extract Promotes Hair Regeneration in C57BL/6 Mice

41 citations , September 2011 in “Journal of Ethnopharmacology”

Panax ginseng extract helps mice grow hair.

research Hair-Growth Promoting Effect of Bimatoprost

1 citations , August 2011 in “Planta Medica”

Bimatoprost effectively promotes hair growth.

research Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism

52 citations , May 2011 in “APOPTOSIS”

Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.

research Proteomics Demonstration That Histone H4 Is a Colchicine-Induced Retro-Modulator of Growth and Alkaline Phosphatase Activity in Hair Follicle Dermal Papilla Culture

5 citations , March 2011 in “Journal of proteomics”

Histone H4, released by cells exposed to colchicine, can cause hair loss by inhibiting cell growth and enzyme activity.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations , February 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

research L-Ascorbic Acid 2-Phosphate Represses Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Balding Dermal Papilla Cells

13 citations , November 2010 in “Experimental Dermatology”

Vitamin C derivative reduces hair loss-related protein in cells.

research Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells

31 citations , October 2010 in “BMB Reports”

L-threonate may help prevent balding by blocking a key protein.

research Erythropoietin Promotes Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations , May 2010 in “Journal of Dermatological Science”

Erythropoietin helps hair grow and could be a potential treatment for hair loss.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations , January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations , December 2009 in “Journal of Dermatological Science”

Fat tissue stem cells may help increase hair growth.

research L-Ascorbic Acid 2-Phosphate Promotes Elongation of Hair Shafts via the Secretion of Insulin-Like Growth Factor-1 from Dermal Papilla Cells Through Phosphatidylinositol 3-Kinase

34 citations , March 2009 in “British journal of dermatology/British journal of dermatology, Supplement”

Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.

research Hair Growth Regulation by the Extract of Aromatic Plant Erica Multiflora

22 citations , March 2009 in “Journal of Natural Medicines”

Erica multiflora plant extract can help hair grow by stimulating growth-related cells and triggering hair cycle changes.

research TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis

43 citations , March 2009 in “Journal of Cellular and Molecular Medicine”

TGF-β2 plays a key role in human hair growth and development.

research Angiogenin Is Expressed in Human Dermal Papilla Cells and Stimulates Hair Growth

20 citations , October 2008 in “Archives of dermatological research”

Angiogenin helps hair grow by stimulating cell growth and blood vessel formation.

research Medical Treatments for Male and Female Pattern Hair Loss

212 citations , September 2008 in “Journal of The American Academy of Dermatology”

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Trans-3,4'-Dimethyl-3-Hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor Beta 2 (TGF-Beta2) Through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

research Trans-3,4'-Dimethyl-3-Hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor Beta 2 (TGF-Beta2) Through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes

10 citations , January 2008 in “Biological and Pharmaceutical Bulletin”

t-Flavanone may help hair growth by reducing a specific protein's activity in skin cells.

Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

research Transcriptional Activation of CCN1 and CCN2, Targets of Canonical Wnt Signal, by Ascorbic Acid 2-Phosphate in Human Dermal Papilla Cells

14 citations , November 2007 in “Journal of Dermatological Science”

Vitamin C derivative may promote hair growth by activating specific genes.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research The Effect of Tripeptide-Copper Complex on Human Hair Growth In Vitro

39 citations , July 2007 in “Archives of Pharmacal Research”

A tripeptide-copper complex may help hair grow by increasing cell growth and decreasing cell death.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

Caffeine can stimulate hair growth and counteract testosterone's suppressive effects on hair follicles.

research Sanguisorba Officinalis Root Extract Has FGF-5 Inhibitory Activity and Reduces Hair Loss by Prolonging the Anagen Period

3 citations , January 2007 in “Nishinihon hifuka/Nishi Nihon hifuka”

Great Burnet extract may prevent hair loss by extending the hair growth phase.

research Promotive Effect of Minoxidil Combined with All-Trans Retinoic Acid (Tretinoin) on Human Hair Growth In Vitro

41 citations , January 2007 in “Journal of Korean Medical Science”

Minoxidil and ATRA together boost hair growth more effectively than minoxidil alone.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro

32 citations , January 2007 in “Biological & Pharmaceutical Bulletin”

Minoxidil and retinol together help hair grow.

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

Green tea component EGCG could potentially promote human hair growth.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Influence of Interleukin-1α on Androgen Receptor Expression and Cytokine Secretion by Cultured Human Dermal Papilla Cells

14 citations , September 2006 in “Experimental Dermatology”

Interleukin‐1 α reduces androgen receptor levels and increases certain cytokines in human scalp cells.

research The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta?

65 citations , May 2006 in “Journal of Investigative Dermatology”

Dexamethasone may influence hair growth by altering estrogen receptor activity in hair cells.

research Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells

22 citations , April 2006 in “Journal of Dermatological Science”

Vitamin C derivative increases versican in cells, potentially aiding hair growth.

research The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative

33 citations , January 2006 in “Journal of Dermatological Science”

A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.

research The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation

87 citations , March 2005 in “Journal of Dermatological Science”

Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , March 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

research Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

55 citations , September 2003 in “Experimental Dermatology”

PDGF signaling may play a role in hair growth cycle regulation.

research Animal and In Vitro Models for the Study of Hair Follicles

45 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Understanding hair follicles through various models can help develop new treatments for hair disorders.

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

research The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation

75 citations , October 2002 in “Journal of Dermatological Science”

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

research Hair Growth Effect of Minoxidil

25 citations , January 2002 in “Folia Pharmacologica Japonica”

Minoxidil helps hair grow by improving blood flow and increasing growth factors in hair follicles.

Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

research Minoxidil-Induced Hair Growth Is Mediated by Adenosine in Cultured Dermal Papilla Cells: Possible Involvement of Sulfonylurea Receptor 2B as a Target of Minoxidil

83 citations , December 2001 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

research Proliferating Effect of Extracts from Woods and Fungi on Rat Vibrissa Dermal Papilla Cells

1 citations , October 2001 in “Journal of Wood Science”

Some extracts from woods and fungi can promote hair growth better than a known hair growth substance.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

research Animal Models and Culture Methods in the Study of Hair Growth

11 citations , March 2001 in “Clinics in dermatology”

The new microneedle method delivers hair loss treatment more effectively by enhancing growth pathways.

Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp

research Minoxidil Increases 17β-Hydroxysteroid Dehydrogenase and 5α-Reductase Activity in Cultured Human Dermal Papilla Cells from Balding Scalp

34 citations , February 1999 in “Journal of Dermatological Science”

Minoxidil boosts enzymes that help hair growth.

research Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells

21 citations , January 1999 in “Endocrine”

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations , February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

research Inhibitory Effects of bFGF, VEGF, and Minoxidil on Collagen Synthesis by Cultured Hair Dermal Papilla Cells

23 citations , July 1996 in “Archives of Dermatological Research”

bFGF, VEGF, and minoxidil decrease collagen production in hair cells, possibly affecting hair growth.

research Regulation of Human Dermal Papilla Cell Production of Insulin-Like Growth Factor Binding Protein-3 by Retinoic Acid, Glucocorticoids, and Insulin-Like Growth Factor-1

37 citations , June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research Effects of Hypertrichotic Agents on Follicular and Nonfollicular Cells In Vitro

28 citations , January 1996 in “Skin Pharmacology and Physiology”

Minoxidil boosts hair cell growth, while cyclosporin does not.

research Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles

9 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sex hormones and antiandrogens can either stimulate or inhibit human hair follicle cell growth depending on the dose.

Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

research Effects of Epidermal Growth Factor, Fibroblast Growth Factor, Minoxidil, and Hydrocortisone on Growth Kinetics in Human Hair Bulb Papilla Cells and Root Sheath Fibroblasts Cultured In Vitro

58 citations , June 1987 in “Archives of Dermatological Research”

EGF and FGF boost hair cell growth, hydrocortisone slows it, and minoxidil doesn't affect it.