Antibacterial, Antioxidant, And Cytotoxic Properties Of Eclipta Prostrata Extracts

This study evaluates the antibacterial, antioxidant, and cytotoxic properties of Eclipta prostrata extracts, traditionally used in Asian medicine for skin diseases. The research highlights the enhanced efficacy of fractionated compounds over crude extracts, with minimum inhibitory concentrations (MIC) for antibacterial activity ranging from 0.78 to 1.56 mg/ml and improved antioxidant activity with an IC50 of 0.174 mg/ml. The total phenolic content was significantly higher in fractionated compounds. However, the cytotoxicity assays revealed high cytotoxicity, with IC50 values of 0.06±0.01 mg/ml for fractionated compounds, necessitating further investigation. The findings suggest that E. prostrata extracts, especially fractionated ones, have promising therapeutic potential for treating skin conditions, particularly in aging populations, but caution is needed due to cytotoxicity concerns.