Antidiabetic, Hypolipidemic and Antioxidant Activities of Hibiscus Rosa Sinensis Flower Extract in Alloxan-Induced Diabetes in Rabbits

The study evaluated the antidiabetic, hypolipidemic, and antioxidant activities of Hibiscus Rosa Sinensis flower extract in alloxan-induced diabetic rabbits. Conducted on 36 albino rabbits, the research compared the effects of the flower extract at doses of 50, 100, and 200 mg/kg with glibenclamide, a standard antidiabetic drug. The flower extract demonstrated a more gradual and sustained reduction in blood sugar levels over 72 hours compared to the rapid effect of glibenclamide. Additionally, the extract showed superior lipid-lowering and antioxidant effects. The findings suggested that the flower extract could be a safer and more effective alternative to traditional antidiabetic agents, potentially offering protection against cardiac complications like ischemic heart disease due to its antioxidant properties.