ARTS, an unusual septin, regulates tumorigenesis by promoting apoptosis

June 2022 in “ Biomedicine & Pharmacotherapy ”

Chenbin Bian, Jing Su, Zhuangzhuang Zheng, Jinlong Wei, Huanhuan Wang, Lingbin Meng, Ying Xin, Xin Jiang

TLDR ARTS helps stop tumors by promoting cell death.

The document reviewed the role of ARTS, a unique member of the septin gene family, in regulating tumorigenesis by promoting apoptosis. ARTS was highlighted for its proapoptotic function, distinguishing it from other inhibitors of apoptosis protein (IAP) antagonists due to its stronger tumor suppressor potential. It was found to bind and inhibit XIAP and Bcl-2 directly or assist p53 in degrading Bcl-XL, thereby inhibiting tumor progression. The review also discussed the potential for developing small-molecule drugs that mimic ARTS to enhance its tumor-suppressing effects.

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