Comparison of the Effect of Autogenic and Xenogenic Use of Platelet-Rich Plasma on Rabbit Chondrocutaneous Composite Graft Survival

    January 2023 in “ Journal of Plastic Surgery and Hand Surgery ”
    Hande Akdeniz, Koray Gürsoy, Gokay Baykara, Adile Dikmen, Hilal Özakıncı, Uğur Koçer
    TLDR Autogenic PRP improves graft viability more than xenogenic PRP, but both are effective.
    This study investigated the effects of autogenic and xenogenic platelet-rich plasma (PRP) on the viability of composite grafts in rabbits. Nine rabbits were used, with each ear divided into three groups receiving serum physiologic, autogenic PRP, or human-derived xenogenic PRP. After 3 weeks, evaluations showed that both autogenic and xenogenic PRP improved graft viability compared to the control group. Although autogenic PRP showed better graft viability and less necrosis macroscopically, the difference was not statistically significant. Histopathological analysis revealed significantly higher angiogenesis in the autogenic PRP group. The study concluded that while autogenic PRP had better histopathological results, xenogenic PRP could be a viable alternative for studies requiring macroscopic evaluation.
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