Comparison of the Effect of Autogenic and Xenogenic Use of Platelet-Rich Plasma on Rabbit Chondrocutaneous Composite Graft Survival

January 2023 in “ Journal of Plastic Surgery and Hand Surgery ”

Hande Akdeniz, Koray Gürsoy, Gokay Baykara, Adile Dikmen, Hilal Özakıncı, Uğur Koçer

platelet-rich plasma autogenic PRP xenogenic PRP angiogenesis chondrocutaneous composite graft PRP

TLDR Autogenic PRP improves graft viability more than xenogenic PRP, but both are effective.

This study investigated the effects of autogenic and xenogenic platelet-rich plasma (PRP) on the viability of chondrocutaneous composite grafts in rabbits. Nine rabbits were used, with each ear receiving two grafts and divided into three groups: control, autogenic PRP, and xenogenic PRP. Results showed that both autogenic and xenogenic PRP improved graft viability compared to the control group. Although autogenic PRP showed better graft viability and less necrosis macroscopically, the difference was not statistically significant. Histopathological analysis revealed significantly higher CD31 staining, indicating better angiogenesis, in the autogenic PRP group. The study concluded that while autogenic PRP had better histopathological outcomes, xenogenic PRP could be a viable alternative for studies requiring macroscopic evaluation.

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research Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia

24 citations , November 2017 in “Aesthetic Plastic Surgery”

All types of Platelet-Rich Plasma (PRP) can treat hair loss, but homologous PRP works best due to its higher platelet count and growth factors from multiple donors.