Autoimmune Skin Diseases In The Era Of COVID-19: Pathophysiological Insights And Clinical Implications

    September 2025 in “ Microorganisms ”
    Aikaterini Ι. Liakou, Eleni Routsi, Kalliopi Plisioti, Eleni Tziona, Dimitra Koumaki, Magdalini Kalamata, Evangelia‐Konstantina Bompou, Rozeta Sokou, Πέτρος Ιωάννου, Stefanos Bonovas, George Samonis, Andreas G. Tsantes, Alexander J. Stratigos
    TLDR COVID-19 can worsen autoimmune skin diseases and increase their occurrence.
    The document reviews the complex relationship between COVID-19 and autoimmune skin diseases (ASDs), such as alopecia areata, psoriasis, and hidradenitis suppurativa, highlighting that SARS-CoV-2 can trigger or exacerbate these conditions through mechanisms like immune dysregulation and cytokine signaling. Epidemiological data indicate increased incidence and flares of ASDs post-COVID-19 infection and vaccination, with mRNA vaccines posing a higher risk for hidradenitis suppurativa flares. Despite initial concerns, biologic therapies for psoriasis and HS do not appear to increase COVID-19 severity. The review underscores the importance of continued research to understand these interactions and improve patient management, emphasizing individualized vaccination planning and long-term monitoring for patients with autoimmune skin diseases.
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