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GlossarymRNA vaccine

uses genetic instructions to trigger an immune response

An mRNA vaccine, or messenger RNA vaccine, is a type of vaccine that uses a small piece of the genetic material from a virus to instruct cells in the body to produce a protein that triggers an immune response. This immune response helps the body recognize and fight the actual virus if it is encountered in the future. Unlike traditional vaccines, which often use weakened or inactivated forms of a virus, mRNA vaccines do not contain live virus particles, making them quicker and easier to produce.

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Research

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Clinical and Immunological Impact of Booster Immunization With Recombinant mRNA Vaccines for SARS-CoV-2 in Patients With Pemphigus and Bullous Pemphigoid

research 219 Clinical and immunological impact of booster immunization with recombinant mRNA vaccines for SARS-CoV-2 in patients with pemphigus and bullous pemphigoid

April 2023 in “Journal of Investigative Dermatology”

Booster shots of mRNA vaccines for COVID-19 increased protective antibodies without worsening autoimmune skin conditions in patients.

research Exacerbation of systemic lupus erythematosus after receiving mRNA‐1273‐based coronavirus disease 2019 vaccine

7 citations , February 2022 in “The Journal of Dermatology”

The mRNA-1273 COVID-19 vaccine may worsen symptoms in people with systemic lupus erythematosus.

research Exacerbation of subacute cutaneous lupus erythematosus following vaccination with BNT162b2 mRNA vaccine

33 citations , June 2021 in “Dermatologic Therapy”

COVID-19 vaccines can trigger autoimmune flares but are still beneficial for patients with autoimmune conditions.

research Polysaccharide, Conjugate, and mRNA-based Vaccines are Immunogenic in Patients with Netherton Syndrome

1 citations , October 2024 in “Journal of Clinical Immunology”

Vaccines work well in Netherton syndrome patients, similar to healthy people.

research Viruses, Variants, and Vaccines: How COVID-19 Has Changed the Way We Look at Skin

1 citations , October 2022 in “Current Dermatology Reports”

COVID-19 and vaccines cause various skin reactions and highlight the need for dermatologists in managing these issues and addressing vaccine distribution disparities.

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community Genomic Sequencing for Hair Loss

in Research/Science 156 upvotes 3 months ago

Hair loss treatments like Minoxidil, finasteride, and potential mRNA therapies are discussed. There is skepticism about targeting specific genes due to the complex genetic nature of hair loss.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community Everyone is hoping for the success of pyri. Has anyone invested money in it?

in Chat 3 years ago

Investing in pharmaceutical products to treat hair loss and the potential risks associated with that, as well as other treatments such as Minoxidil, Finasteride, RU58841, and a COVID-19 booster.

community When could we expect pp405 to hit the market?

in Research/Science 31 upvotes 1 year ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

community Wouldn’t it be funny if there already was a drug that existed which reactivated sleeping follicles? It would be our own version of Ozempic

in Research/Science 202 upvotes 1 year ago

PP405 shows promise for reactivating hair follicles, with potential maintenance using 5AR inhibitors. Current treatments like Minoxidil and finasteride are effective but have limitations, and there is hope for more effective solutions in the future.

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