Autophagy-Mediated Cellular Remodeling During Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages

October 2024 in “ Cells ”

Leopold Eckhart, Флориан Грубер, Supawadee Sukseree

autophagy keratinocytes epidermis skin appendages lysosome-dependent degradation cellular remodeling programmed cell death epithelial differentiation

TLDR Autophagy is essential for proper skin cell development and function.

This document discusses the role of autophagy in the differentiation of keratinocytes, which are essential for the formation of the epidermis and skin appendages like hair and nails. Autophagy, a lysosome-dependent degradation process, is crucial for remodeling cellular components during keratinocyte differentiation. Blocking autophagy significantly affects the properties of the resulting differentiation products. The study presents a model where autophagy-mediated degradation of organelles and proteins is vital for cellular remodeling, comparing it to other degradation mechanisms and its role in programmed cell death during epithelial differentiation.

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