Electrospun Radially Oriented Berberine-PHBV Nanofiber Dressing Patches for Accelerating Diabetic Wound Healing

January 2024 in “ Regenerative Biomaterials ”

Qiuyu Wang, Sai Zhang, Jiayi Jiang, Shaojuan Chen, Seeram Ramakrishna, Wenwen Zhao, Fan Yang, Shaohua Wu

berberine poly(3-hydroxybutyrate-co-3-hydroxyvalerate) PHBV electrospinning nanofiber collagen deposition re-epithelialization neovascularization hair follicles Beri

TLDR The new nanofiber patch speeds up diabetic wound healing and improves healing quality.

The study explores the use of electrospun radially oriented berberine-PHBV nanofiber dressing patches to enhance diabetic wound healing. These patches, which incorporate berberine for its antimicrobial and anti-inflammatory properties, significantly accelerated wound healing in diabetic mice, achieving 100% wound closure in 18 days. The radially oriented nanofibers improved mechanical properties and biological functions, promoting cell adhesion, proliferation, and angiogenesis. The PHBV-Radially + 5%Beri group showed the highest wound healing rate and regeneration of hair follicles. This innovative dressing material shows promise for improving wound care in diabetic patients due to its favorable mechanical properties and enhanced healing effects.

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Electrospun Radially Oriented Berberine-PHBV Nanofiber Dressing Patches for Accelerating Diabetic Wound Healing

Research cited in this study

research State-Of-The-Art Review Of Electrospun Gelatin-Based Nanofiber Dressings For Wound Healing Applications

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