Engineered Bilayer Hydrogel with Spatiotemporal Drug and Oxygen Delivery for Diabetic Wound Microenvironment Reprogramming

    December 2025 in “ Regenerative Biomaterials ”
    Huaping Li, Quan Chen, Bihua Liang, Huiyan Deng, Chao Bi, Liqian Peng, Jiaoquan Chen, S. Ou, Li Zhang, Ziyan Chen, Huilan Zhu
    TLDR The hydrogel effectively heals diabetic wounds by reducing inflammation, providing oxygen, and preventing infection.
    This study introduces an innovative bilayer hydrogel (Ca@Q-E@SGH) designed for diabetic wound healing by addressing inflammation, hypoxia, and infection. The hydrogel features a core component that releases EGCG in response to ROS/glucose, promoting macrophage transition from M1 to M2 to reduce inflammation. It also provides sustained oxygen release to aid vascularization during tissue remodeling. The bilayer structure offers protective functions, with a lower layer encapsulating nanoparticles and an upper layer preventing pathogen adhesion. This approach achieved a 99.1% wound closure rate by day 14, demonstrating a comprehensive strategy for diabetic wound management through intelligent drug release, oxygen delivery, and anti-fouling protection.
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