Comparative Evaluation of the Biocompatibility of Sponges Based on Different Chitosan Salts In Vitro

The study evaluates the biocompatibility of sponges made from chitosan modified with glycolic, lactic, and ascorbic acids for potential use in wound dressings. Chitosan glycolate and lactate sponges showed good biocompatibility, supporting cell survival and metabolic activity, with glycolate sponges also demonstrating high blood sorption capacity (over 700 μl/cm³). In contrast, chitosan ascorbate sponges inhibited cell viability and metabolic activity, with lower blood sorption capacity (250 μl/cm³). The results suggest that chitosan glycolate and lactate sponges are promising for wound-healing applications, while chitosan ascorbate sponges need further investigation.