A Facile and Biocompatible Hydrogel Based on Oxidized Brachybotrys Paridiformis Polysaccharide for Enhanced Wound Healing

    March 2026 in “ ACS Omega ”
    Na Zou, Jie Zhou, Xifan Mei, Qing Chen, Sitong Wu
    TLDR The hydrogel significantly speeds up wound healing and improves skin recovery.
    The study developed a hydrogel wound dressing using oxidized Brachybotrys paridiformis polysaccharide (OBPP) and O-carboxymethyl chitosan (CMCS), which demonstrated excellent biocompatibility and enhanced wound healing capabilities. The hydrogel promoted human umbilical vein endothelial cells migration and showed superior in vivo wound-healing performance, with the hydrogel-treated group achieving significantly smaller wound areas by day 9 (7.59 ± 1.83%) compared to the control group (44.14 ± 18.22%). By day 15, the hydrogel group exhibited nearly complete healing with smooth, scab-free skin, highlighting its potential as an effective wound dressing.
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