Biological Function of Long Non-coding RNA (LncRNA) Xist

    June 2021 in “ Frontiers in Cell and Developmental Biology ”
    Wenlun Wang, Lu Min, Xinyuan Qiu, Xiaomin Wu, Chuanyang Liu, Jiaxin Ma, Dongyi Zhang, Lingyun Zhu
    TLDR LncRNA Xist is crucial for X-chromosome inactivation and may be a target for treating diseases like cancer and heart issues.
    The document reviewed the biological functions of long non-coding RNA (lncRNA) Xist, emphasizing its role in X-chromosome inactivation and its involvement in various diseases, particularly cancer. LncRNA Xist regulated gene expression by acting as a competing endogenous RNA (ceRNA) and was implicated in the progression of multiple cancer types, including breast, lung, and liver cancer, by interacting with microRNAs and signaling pathways. It also played a role in non-cancer diseases such as cardiac diseases and neuropathic pain. Additionally, lncRNA Xist was involved in hair follicle regeneration by regulating the miR-424/Shh axis. The document suggested that lncRNA Xist could be a potential biomarker and therapeutic target across various diseases.
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