Longitudinal Biomarker Trajectories Accompanying Trichoscopic Change After PRP-Based Regimens for Alopecia: A Complementary Multi-Marker Analysis of a Real-World Cohort

This study investigates the longitudinal biomarker trajectories in 129 participants undergoing PRP-based regimens for nonscarring alopecia. The research focuses on trichoscopic changes and paired biomarker trajectories, rather than baseline response stratification. Participants received treatments including PRP, PRP + exosomes, PRP + nutricomplex, or nutricomplex alone, with assessments at baseline (T1) and follow-up (T2). Results showed an increase in total hair density from T1 to T2, though the improvement varied among individuals. The study found heterogeneous paired trajectories in CBC-derived inflammatory indices and soluble markers, with some biomarker changes correlating with hair density changes. This analysis highlights the complexity of interpreting response heterogeneity through clinical-biomarker dynamics rather than a single endpoint.