Biomaterials Mimicking Mechanobiology: A Specific Design for a Specific Biological Application

The document reviews the design of biomaterials that mimic the mechanobiological properties of the extracellular matrix (ECM) to regulate cellular functions, emphasizing the role of mechanosensing and mechanotransduction pathways. It discusses the use of natural and synthetic polymers to create biomaterials with tailored properties for biomedical applications, highlighting their biocompatibility and structural advantages. The document explores various structures like films, scaffolds, hydrogels, and nanoparticles, each offering unique properties for tissue engineering and regenerative medicine. It underscores the importance of biocompatibility, biodegradability, and mechanical properties in biomaterials, with applications in bone, neural, cardiac, and skeletal muscle regeneration, as well as dental pulp and cartilage repair. The review also highlights advancements in biomaterials for wearable electronics, biosensors, and targeted cancer therapy, aiming for clinical applicability and scalability.