Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Scaffold-based drug delivery systems present a promising approach for oral cancer treatment by enabling targeted and localized drug delivery, which reduces systemic side effects and enhances therapeutic efficacy. These systems utilize biocompatible and biodegradable materials to encapsulate drugs, allowing for controlled and sustained release at the tumor site. This method improves drug concentration in tumor tissues, minimizes damage to healthy cells, and reduces the need for repeated chemotherapy cycles. Innovations such as smart scaffolds and dual drug-loaded nanofibrous scaffolds further enhance treatment efficacy by providing sequential therapy and synergistic effects. Despite challenges like fabrication complexity and biocompatibility, ongoing research aims to overcome these limitations, making scaffold-based systems a valuable avenue for improving oral cancer therapies.