TLDR The new biomimetic skin heals wounds faster and better than traditional treatments, without scarring.
This study introduces a biomimetic multilayer composite scaffold system, combining a decellularized amniotic membrane matrix with fibroblast-laden collagen gel and epidermal stem cells, to promote full-thickness skin wound regeneration. The innovative bionic skin, AM-FCG-EpiSCs, demonstrated superior healing compared to traditional treatments, such as Moropicin ointment, by facilitating quicker recovery and regenerating skin appendages like hair follicles without scarring. The biomimetic structure effectively mediates cell interactions and regulates the microenvironment, addressing the challenges of scar suppression and functional restoration, and presents a promising advancement for translational medicine.
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28 citations
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October 2024 in “Advanced Materials” Artificial skin can heal wounds without scars and regenerate hair, oil, and sweat glands.
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October 2024 in “Molecules and Cells” Epidermal stem cells work with the skin's environment to heal wounds effectively.
19 citations
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August 2024 in “Journal of Translational Medicine” Epidermal stem cells are vital for skin healing and have potential for treating skin disorders.
March 2024 in “Advanced healthcare materials/Advanced Healthcare Materials” Scientists developed a new way to create skin-like structures from stem cells using a special 3D gel and a device that improves cell organization and increases hair growth.
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February 2024 in “Nature cell biology” Mechanical forces are crucial for shaping cells and forming tissues during development.
54 citations
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October 2023 in “Oncogene” p63 is essential for controlling epithelial stem cells and tissue health.
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June 2020 in “Cell stem cell” Skinny fat cells help wounds heal faster by releasing fatty acids.
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February 2023 in “International Journal of Molecular Sciences” The fascial layer is a promising new target for wound healing treatments using biomaterials.
43 citations
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July 2019 in “Stem Cells International” Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.
PlacMA hydrogels from human placenta are versatile and useful for cell culture and tissue engineering.
70 citations
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August 2020 in “Nanomaterials” Electrospun nanofibers show promise for enhancing blood vessel growth in tissue engineering but need further research to improve their effectiveness.
27 citations
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May 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” The best method for urethral reconstruction is using hypoxia-preconditioned stem cells with autologous cells on a vascularized synthetic scaffold.
