Cell-Laden Gel Biomimetic Skin Promotes Full-Thickness Skin Wound Regeneration

The study introduces a novel biomimetic skin system, AM-FCG-EpiSCs, designed to enhance full-thickness skin wound regeneration without scarring. This system integrates a decellularized amniotic membrane with fibroblast-laden collagen gel and epidermal stem cells, promoting hierarchical regeneration and restoration of skin appendages like hair follicles. In a goat model, wounds treated with AM-FCG-EpiSCs showed a 72.1% healing rate by day 60, significantly outperforming the 40.1% in the control group. By day 100, the experimental group's wounds were nearly closed, demonstrating better UV resistance and hair growth. The study highlights the potential of this approach for scarless skin repair and appendage regeneration, suggesting its promise for clinical applications, although further in vivo studies are needed for confirmation.