P63: A Crucial Player In Epithelial Stemness Regulation

October 2023 in “ Oncogene ”

Yanan Li, Sara Giovannini, Tingting Wang, Jiankai Fang, Peishan Li, Changshun Shao, Ying Wang, Massimiliano Agostini, Pierluigi Bove, Alessandro Mauriello, Giuseppe Novelli, Mauro Piacentini, Valentina Rovella, Manuel Scimeca, Giuseppe Sica, Qiang Sun, Giuseppe Tisone, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

TLDR p63 is essential for controlling epithelial stem cells and tissue health.

The document reviews the role of p63, a key transcription factor, in regulating epithelial stem cell (ESC) activities such as self-renewal, differentiation, and proliferation. p63 is crucial for epithelial tissue homeostasis and development, influencing gene transcription related to cell survival and epithelial-to-mesenchymal transition. The review highlights the diverse effects of p63 isoforms, TAp63 and ΔNp63, in both normal epithelial tissues and epithelium-derived cancers. It also discusses the signaling pathways that modulate these isoforms and their impact on stemness regulation.

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Research cited in this study

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research Plasticity of Epithelial Cells During Skin Wound Healing

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Epithelial cells adapt and work together to heal skin wounds effectively.

P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

5 citations , January 2022 in “PloS one”

Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.

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research P63 Expression Pattern During Rat Epidermis Morphogenesis and the Role of P63 as a Marker for Epidermal Stem Cells

16 citations , September 2006 in “Journal of Cutaneous Pathology”

P63 is a marker for epidermal stem cells in rats.

research Expression of Beta-Catenin, p63, and CD34 in Hair Follicles During the Course of Androgenetic Alopecia

4 citations , August 2005 in “Archives of Dermatological Research”

Higher p63 and CD34 levels found in specific scalp areas may affect hair loss progression.

P63: A Crucial Player In Epithelial Stemness Regulation

Research cited in this study

research Plasticity of Epithelial Cells During Skin Wound Healing

research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

research Mechanism of TAp73 Inhibition by ΔNp63 and Structural Basis of p63/p73 Hetero-Tetramerization

research Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

research P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis

research P63 Expression Pattern During Rat Epidermis Morphogenesis and the Role of P63 as a Marker for Epidermal Stem Cells

research Expression of Beta-Catenin, p63, and CD34 in Hair Follicles During the Course of Androgenetic Alopecia