A Multiaxial Bioreactor Integrated With an Environmental Monitoring System for Tissue-Engineered Skin Grafts

January 2026 in “ Advanced Healthcare Materials ”

Seunggyu Jeon, P. T. Lee, Adit Mehta, Naresh Mahajan, Eric Renteria, Frank Marini, Ji Hyun Kim, Tracy Criswell, Thomas Shupe, A. Atala, Metin N. Gürcan, Shay Soker, Joshua Hunsberger, James Yoo, Young Min JU

tissue-engineered skin grafts multiaxial bioreactor dermal fibroblast epidermal keratinocyte regenerative medicine

TLDR The new bioreactor improves skin grafts by evenly stretching cells and monitoring conditions for better growth.

This study introduces a novel multiaxial bioreactor system for tissue-engineered skin grafts, addressing limitations of conventional bioreactors by providing uniform stretching and continuous environmental monitoring. Utilizing a Hoberman ring design, the system applies radial force for multiaxial stretching, resulting in uniform cellular distribution and orientation. Integrated sensors monitor pH, dissolved oxygen, glucose, lactate, and media level, ensuring optimal conditions for tissue maturation. The cyclic multiaxial stretching enhances dermal fibroblast proliferation and epidermal keratinocyte integrity, demonstrating the bioreactor's potential to advance regenerative medicine applications.

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