Bioregenerative Applications of the Human Mesenchymal Stem Cell-Derived Secretome: Part II

May 2024

Vincent S. Gallicchio

mesenchymal stem cell conditioned medium extracellular vesicles secretome cell-free strategies

This literature review evaluates the application of conditioned medium and extracellular vesicles from the mesenchymal stem cell secretome in treating various diseases in animal and human in-vivo models. It highlights the potential benefits and side effects of these therapies, discusses ongoing clinical trials, and suggests future research directions while acknowledging the limitations of cell-free strategies. The findings suggest that the mesenchymal stem cell secretome could be an effective treatment for multiple diseases, offering a promising alternative to traditional stem cell therapies.

View this study on dx.doi.org →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review

2 citations , October 2022 in “Journal of Biomedical Science”

Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.

research Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis

12 citations , August 2022 in “Journal of Controlled Release”

A new microneedle patch effectively promotes hair growth by increasing blood vessel formation around hair follicles.

research Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia

6 citations , February 2022 in “Journal of immunology research”

Exosomes from fat-derived stem cells can potentially improve hair growth and could be a new treatment for immune-related hair loss.

research Dental Derived Stem Cell Conditioned Media for Hair Growth Stimulation

15 citations , May 2019 in “PLOS ONE”

Substances from dental stem cells might help treat hair loss.

Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

research Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

113 citations , November 2017 in “Scientific Reports”

Tiny particles from stem cells help activate hair growth cells and encourage hair growth in mice without being toxic.

research Effect of Adipose-Derived Stem Cell-Conditioned Medium on the Proliferation and Migration of B16 Melanoma Cells

23 citations , June 2015 in “Oncology Letters”

Adipose-derived stem cell-conditioned medium can reduce melanoma cell growth and spread.

Related Community Posts Join

6 / 23 results

community Lavdik Hair Growth Serum?

in Product 5 years ago

A user is concerned about the legitimacy of a hair growth serum called Lavdik, which they ordered after seeing an ad for Jemros. The product contains ginger extract, ginseng extract, fleece flower root, grape seed oil, glycerol, carbomer, propylene glycol, and rosemary oil, and the user is unsure if it is effective or a scam.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 3 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

in Research/Science 363 upvotes 1 week ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community 2026 Hairloss Nuclear Stack Update

in Finasteride/Dutasteride 78 upvotes 1 week ago

A user shared an extensive hair loss treatment regimen including dutasteride, minoxidil, tadalafil, RU58841, microneedling, and various topical and oral supplements. Responses varied, with some suggesting the regimen is excessive and others offering additional advice or expressing skepticism about its practicality and effectiveness.

Similar Research

6 / 1000+ results

Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review