Effect of Primary Biotin Deficiency on the Skin of Germ-Free and Conventional Mice Fed a Purified Biotin-Deficient Diet Without Supplementation with Egg White

    January 1997 in “ Journal of Clinical Biochemistry and Nutrition ”
    Masamichi IKEDA, Yutaka Uno, Kazuya Hamada, Hitomi Kawabe, Bunsaku Sakakibara
    TLDR Biotin deficiency causes severe hair loss and weight reduction in germ-free mice.
    The study investigated the effects of primary biotin deficiency on growth and skin in germ-free and conventional mice over 57 days. Germ-free mice on a biotin-deficient diet showed significant body weight reduction and severe alopecia, unlike conventional mice. Both groups experienced decreased biotin levels and pyruvate carboxylase activity in various tissues, with germ-free mice showing lower activity levels. Histological analysis revealed degeneration in the hair medulla and cortex in germ-free mice, leading to hair root downgrowth.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Reminder: Biotin supplementation is a scam.

      in Product  112 upvotes 2 years ago
      Biotin supplements are considered ineffective for hair loss and are not supported by evidence. People in the conversation have mixed experiences, with some noting benefits for nails and skin but not hair, while others continue to use biotin as part of their vitamin regimen.

      community 4 months progress - fin/min/keto/biotin

      in Minoxidil  902 upvotes 10 months ago
      A 26-year-old male experienced significant hair regrowth using a 4-in-1 topical treatment from Hims, which includes minoxidil, finasteride, ketoconazole, and biotin, over four months. The user reported increased body and beard hair, skin changes, and no negative sexual side effects, while others noted the rapid and impressive results as atypical.

      community 19 | 9 months Fin & Min update

      in Progress Pictures  758 upvotes 3 years ago
      A user's hair loss journey and their results from 9 months of the treatments finasteride and minoxidil, as well as biotin supplementation. People discussed side effects, taking progress pictures, and providing support to other users on their own journeys.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  63 upvotes 1 year ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

      community Ultimate Hairloss Flowchart (for beginners)

      in Treatment  247 upvotes 2 years ago
      The conversation discusses a hair loss flowchart for beginners, with mixed opinions on its effectiveness. Treatments mentioned include minoxidil, finasteride, dutasteride, microneedling, and vitamins.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 1 year ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

    Related Research

    1 / 1 results