Biotransformation of Tirilazad in Humans: Effect of Finasteride on Tirilazad Clearance and Reduced Metabolite Formation
November 1998
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Research cited in this study
2 / 2 resultsresearch Identification of Human Cytochrome P450 Isozymes Responsible for the In Vitro Oxidative Metabolism of Finasteride
research Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine
Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.
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Finasteride is mainly broken down by the enzyme CYP3A4, affecting its levels in the body.
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Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.
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Finasteride's metabolites were identified, helping understand how the drug is processed in the body.