In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

November 2014 in “ Toxicology Letters ”

Seung Hwan Lee, Jung Tak Park, Do-Yun Kim, Soo Kyung Bae, Young-Won Chin, Euichaul Oh

finasteride UGT1A4 drug-drug interactions Propecia

TLDR Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

The study found that finasteride selectively inhibits the UGT1A4 enzyme in vitro, which could potentially lead to drug-drug interactions in vivo. However, the in vivo concentration of finasteride is not high enough to cause significant inhibition of UGT1A4. The study suggests that caution should be taken when administering drugs that are metabolized by UGT1A4 in combination with finasteride.

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Related Research

1 / 1 results

In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

research In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

13 citations , November 2014 in “Toxicology Letters”

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

Research cited in this study

research Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry

research The Effect of St. John's Wort on the Pharmacokinetics, Metabolism, and Biliary Excretion of Finasteride and Its Metabolites in Healthy Men

research Finasteride 1 mg Has No Inhibitory Effect on Omeprazole Metabolism in Extensive and Poor Metabolizers for CYP2C19 in Japanese

research Finasteride

research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride

research Metabolism of Finasteride in Rat Hepatic Microsomes: Age and Sex Differences and Effects of P450 Inducers

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research Finasteride: The First 5α-Reductase Inhibitor

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