Combined Physicochemical and Transcriptomic Analyses Reveal the Effect of Black Wolfberry Ferment on Alopecia

This study investigated the effects of black wolfberry ferment on androgenetic alopecia (AGA) in mice, revealing that it promotes hair regrowth. Mice were divided into control, model, low-dosage, and high-dosage groups, with AGA induced in all but the control group. The ferment increased hair weight, hair follicle count, and skin thickness, with significant gene expression changes linked to the PI3K/AKT, NF-kappa B, and MAPK pathways. These findings suggest black wolfberry ferment as a potential therapeutic agent for AGA, supported by transcriptomic analysis identifying 1,636 relevant genes.