Complete Blood Collection-Based Systemic Inflammation Biomarkers as a Severity Biomarker in Alopecia Areata: A Cross-Sectional Study

October 2024 in “ Acta Dermato Venereologica ”

Sihan Deng, Jundong Huang, Min Li, Jian Jia, Wei Shi

This study investigated the relationship between systemic inflammation biomarkers and the severity of alopecia areata (AA) in 302 AA patients compared to 296 healthy controls. The study found that AA patients had higher levels of neutrophil/lymphocyte ratio (NLR), systemic immune inflammation index (SII), and white blood cell/lymphocyte ratio (WLR) than healthy controls. Additionally, platelet/lymphocyte ratio (PLR) and SII were significantly higher in patients with severe AA compared to those with mild-to-moderate AA. The risk of severe AA increased with higher levels of PLR, SII, NLR, and WLR, indicating a strong link between systemic inflammation and the severity of AA.

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