BroadAMP-GPT: AI-Driven Generation of Broad-Spectrum Antimicrobial Peptides for Combating Multidrug-Resistant ESKAPE Pathogens

    June 2025 in “ Gut Microbes ”
    Yanru Li, Xiaofang Xu, Xiaohui Zhang, Zhihui Xu, Jiaqi Zhao, Ruiyu Zhu, Ziyu Wang, Wei Ran, Wenqian Zhao, Na Yan, Yifan Leng, Zexu Miao, Xiaomin Wang, Liping Wang, Jinxin Liu, Cong Pian, Jinhu Huang
    TLDR BroadAMP-GPT effectively creates antimicrobial peptides to fight drug-resistant bacteria.
    BroadAMP-GPT is an innovative AI-driven platform designed to efficiently generate and validate antimicrobial peptides (AMPs) to combat multidrug-resistant ESKAPE pathogens. The study found that 57% of AI-generated AMPs were effective against these pathogens. A standout candidate, AMP_S13, exhibited remarkable stability across various physiological conditions and demonstrated low toxicity. It also proved effective in vivo, reducing mortality in an infection model and promoting wound healing in a skin infection model. This platform represents a significant advancement in the rapid discovery of stable, broad-spectrum AMPs with low toxicity, addressing the critical issue of antimicrobial resistance.
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