BroadAMP-GPT: AI-Driven Generation of Broad-Spectrum Antimicrobial Peptides for Combating Multidrug-Resistant ESKAPE Pathogens

    June 2025 in “ Gut Microbes ”
    Yanru Li, Xiaofang Xu, Xiaohui Zhang, Zhihui Xu, Jiaqi Zhao, Ruiyu Zhu, Ziyu Wang, Wei Ran, Wenqian Zhao, Na Yan, Yifan Leng, Zexu Miao, Xiaomin Wang, Liping Wang, Jinxin Liu, Cong Pian, Jinhu Huang
    TLDR BroadAMP-GPT effectively creates antimicrobial peptides to fight drug-resistant bacteria.
    The study introduces BroadAMP-GPT, an AI-driven framework for generating antimicrobial peptides (AMPs) to combat multidrug-resistant ESKAPE pathogens. The platform successfully identified potent AMPs, notably AMP_S13, which demonstrated exceptional stability, low cytotoxicity, and strong in vivo efficacy, reducing mortality and accelerating wound healing in infection models. The peptides work by disrupting bacterial membranes, leading to rapid bactericidal effects with minimal resistance development. BroadAMP-GPT offers a scalable and comprehensive platform for AMP discovery, outperforming traditional methods and highlighting the potential of AI in designing effective antimicrobial agents against resistant pathogens.
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