A Case of Bullous Pemphigoid in a Malignant Melanoma Patient Following an Increased Th2/Th1 Ratio in Peripheral Blood Cells After Nivolumab Treatment
October 2023
in “
European Journal of Dermatology
”
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This document discusses a case of bullous pemphigoid (BP) in a patient with malignant melanoma following treatment with nivolumab, an anti-PD-1 antibody. Nivolumab is used to enhance anti-tumor immune responses by activating cytotoxic CD8+ T cells and CD4+ T helper (Th) cells. However, this activation can lead to immune-related adverse events (irAEs), such as BP, due to non-specific T cell-mediated immune responses. The case highlights the increased Th2/Th1 ratio in peripheral blood cells after nivolumab treatment, suggesting a potential mechanism for the development of BP as an irAE.
