Calcipotriene/Betamethasone in the Treatment of Psoriasis: A Review Article

August 2009 in “ Expert opinion on pharmacotherapy ”

Rosita Saraceno, Talia Gramiccia, Pasquale Frascione, Sergio Chimenti

calcipotriene betamethasone dipropionate topical corticosteroids vitamin D3 analogues keratinocyte differentiation antiproliferative effects anti-inflammatory properties plaque-type psoriasis scalp psoriasis nail psoriasis topical steroids vitamin D3

TLDR The combination of calcipotriene and betamethasone is more effective and has fewer side effects for treating psoriasis.

Plaque-type psoriasis, affecting approximately 1-3% of the Caucasian population, was commonly treated with topical corticosteroids and vitamin D3 analogues. The combination of calcipotriene and betamethasone dipropionate optimized treatment by merging the keratinocyte differentiation and antiproliferative effects of vitamin D3 analogues with the anti-inflammatory properties of steroids. This combination enhanced effectiveness and reduced side effects compared to using a single topical agent. The review highlighted the benefits of this combination therapy for localized plaque-type, scalp, and nail psoriasis.

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research Psoriasis of the Scalp: Diagnosis and Management

128 citations , January 2001 in “American Journal of Clinical Dermatology”

Coal tar shampoos, salicylic acid, and topical corticosteroids are effective for scalp psoriasis, with Vitamin D3 analogues also showing benefits; severe cases may require stronger medication with more risks.