The Emerging Fungal Pathogen Candida Auris Induces IFNγ to Colonize Mammalian Hair Follicles

The study investigates the behavior of the emerging fungal pathogen Candida auris, known for its antifungal resistance and ability to cause deadly outbreaks, particularly focusing on its colonization of hair follicles. Using a mouse skin colonization model, researchers found that C. auris has a higher tendency to colonize hair follicles compared to its relative C. albicans. Unlike C. albicans, which triggers an effective antifungal immune response, C. auris induces a type 1 immune response characterized by IFNγ production. This response, rather than clearing the fungus, aids its colonization by weakening the epithelial barrier and suppressing antifungal defenses in hair follicle keratinocytes. The findings suggest that C. auris exploits specific immune responses to persist in hair follicles.