Morphologic and Immunologic Characterization of a Canine Isthmus Mural Folliculitis Resembling Pseudopelade of Humans
March 2000
in “
Veterinary Dermatology
”
isthmus mural folliculitis pseudopelade alopecia lymphocyte infiltration follicular isthmus hair bulb epidermis follicular atrophy sebaceous gland atrophy CD3 lymphocytes CD8 lymphocytes autoantibodies hair follicle proteins hair keratins adnexal unit atrophy hair loss hair thinning immune response skin inflammation
TLDR Dogs have a skin condition like human pseudopelade, causing hair loss that doesn't improve with treatment.
The study characterized a novel form of isthmus mural folliculitis in dogs, resembling human pseudopelade. Clinically, affected dogs showed persistent alopecia that did not respond to immunosuppressive therapy. Histopathological analysis revealed lymphocyte infiltration in the follicular isthmus, with inflammation sometimes extending but not involving the hair bulb or epidermis. All dogs exhibited severe follicular and sebaceous gland atrophy. The presence of CD3 and CD8 lymphocytes and autoantibodies targeting lower hair follicle proteins, including hair keratins and trichohyalin, were noted. The lack of hair regrowth and specific inflammation patterns were similar to human pseudopelade.
