Differential Cardiometabolic Outcomes of Leuprolide Versus Spironolactone in Women With Polycystic Ovary Syndrome

December 2025 in “ Baylor University Medical Center Proceedings ”

Myles Goliger, Michael Kozlov, Esther Auerbach, Jacob Givoni, Robert A. Adler, Jeffrey P. Weiss, Jason Lazar

leuprolide spironolactone polycystic ovary syndrome PCOS lipid profiles hypertension Lupron Aldactone

TLDR Leuprolide may better manage cholesterol and blood pressure in PCOS than spironolactone.

A recent study compared the cardiometabolic outcomes of leuprolide versus spironolactone in women with polycystic ovary syndrome (PCOS). The results indicated that leuprolide therapy was associated with improved lipid profiles and better management of hypertension compared to spironolactone. These findings suggest that leuprolide may have a potential role in the broader metabolic management of PCOS.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Causal Relationship Between Inflammatory Cytokines and Polycystic Ovary Syndrome: A Bidirectional Mendelian Randomization Study

12 citations , November 2024 in “Journal of Ovarian Research”

Certain inflammatory factors may increase or decrease the risk of developing PCOS.

research Beyond Hormones: A Systematic Review of the Risk of Cardiovascular Diseases in Polycystic Ovary Syndrome

10 citations , November 2024 in “Cureus”

Women with PCOS have a higher risk of heart disease due to factors like insulin resistance and obesity.

research Polycystic Ovarian Syndrome: Exploring Hypertension and Cardiometabolic Implications

4 citations , October 2024 in “Cureus”

PCOS may increase the risk of high blood pressure and heart issues.

research The Efficacy and Safety of Oral and Topical Spironolactone in Androgenetic Alopecia Treatment: A Systematic Review

March 2023 in “Clinical, Cosmetic and Investigational Dermatology”

Spironolactone can effectively treat hair loss with manageable side effects.

research Effects of Low-Dose Spironolactone Combined with Metformin or Either Drug Alone on Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Pilot Study

8 citations , March 2022 in “International Journal of Endocrinology”

Combining spironolactone with metformin reduces insulin resistance in PCOS better than either drug alone.

research Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth

222 citations , January 2014 in “International journal of reproductive medicine”

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

research The Metabolic Effects of Drugs Used for the Treatment of Polycystic Ovary Syndrome

2 citations , September 2013 in “Journal of the Turkish-German Gynecological Association”

Drugs for PCOS can affect metabolism, so understanding their effects is important for managing health risks.

research Relationship Between Androgen Levels and Blood Pressure in Young Women With Polycystic Ovary Syndrome

166 citations , March 2007 in “Hypertension”

High androgen levels in young women with PCOS are linked to higher blood pressure.

Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial

research Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double-Blind, Placebo-Controlled Trial

94 citations , January 2000 in “The Journal of Clinical Endocrinology and Metabolism”

Spironolactone most effective for hirsutism, but has side effects.

Similar Research

5 / 247 results

research Hirsutism and Acne in Polycystic Ovary Syndrome

169 citations , August 2004 in “Baillière's best practice & research. Clinical obstetrics & gynaecology/Baillière's best practice and research in clinical obstetrics and gynaecology”

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

research Managing the PCOS-Related Symptoms of Hirsutism, Acne, and Hair Loss

1 citations , August 2013 in “Springer eBooks”

Birth control pills and anti-androgen medications help manage hair growth, acne, and hair loss in women with PCOS.

research The Evaluation and Management of Hirsutism

11 citations , May 2003 in “Obstetrics and gynecology (New York. 1953. Online)/Obstetrics and gynecology”

Hirsutism in women often indicates a hormonal imbalance and can be managed with a combination of hormonal treatments and hair removal methods.

research Hirsutism

10 citations , May 1995 in “Journal of General Internal Medicine”

Most women with excessive hair growth have PCOS; treatment varies and focuses on preventing new hair, with electrolysis as the only permanent removal method.

research Obesity and Polycystic Ovary Syndrome

28 citations , November 2007 in “Medical Clinics of North America”

Obesity worsens Polycystic Ovary Syndrome symptoms, and weight loss is a key treatment.