The Concealed Side of Caspases: Beyond a Killer of Cells
December 2024
in “
Cellular and Molecular Life Sciences
”
TLDR Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.
Caspases, traditionally known for their role in apoptosis, have been found to play diverse roles in cell proliferation, differentiation, and invasion, with their deregulation contributing to cancer, inflammation, neurodegenerative disorders, and skin pathologies. Recent research highlights the potential of caspase inhibitors in therapeutic applications, though challenges remain in minimizing side effects. The document explores the evolution of caspase research, emphasizing their roles beyond cell death and the potential for developing effective caspase-targeted therapies.
